Aliaksandra Lisouskaya (Alexandra Lisovskaya)
Belarusian State University, Minsk, Belarus, M.Sc. Chem.(2009), Ph.D.(2012)
Phone: (574) 631-5457
Email: alisousk@nd.edu
Office: 105C Radiation Research Building
Radiation Chemistry and Photochemistry in Aqueous Solutions
Scientific Interests
Pulse Radiolysis of Aqueous Media
Kinetics and mechanisms of radical reactions at high temperatures – reactor water radiolysis. Pulse radiolysis of hyper-reduced transition metal ions over wide temperature ranges. Time-resolved spectra of transients formed in one-electron reduction and oxidation reactions.
Free Radical and Redox Chemistry of Bioorganic Compounds
Mechanisms of free radical reactions of organic compounds and biomolecules probed by pulse radiolysis and EPR spectroscopy. Detection and characterization of radical intermediates derived from irradiated organic compounds. Direct and sensitized photodestruction of organic compounds.
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Recent Accomplishments
One-electron redox kinetics of M2+/+ couples
This work has focused on minimizing the very large uncertainty in the reduction potentials of aqueous ion pairs Co2+/+ and Ni2+/+, by measuring the reactions of the metal species with various reaction partners having known reduction potentials. Measurement of the reduction reactions for Co2+/+ was greatly complicated by the self-catalyzed clustering reactions. Electron transfer reactions in aqueous M2+/+ ions are complicated by the reorganization of the solvation shell.
Spin-trapping Free Radicals in Irradiated Ionic Liquids
Room temperature ionic liquids (RTILs) have been suggested for use as liquid extractants for nuclear fuel reprocessing. However, radicals, formed during radiolysis of RTILs, have been detected by spin-trapped EPR and indicate RTIL degradation. Well-resolved motionally narrowed EPR spectra for the trapped radicals were obtained by dilution of several typical RTILs with CH2Cl2 after irradiation. Trapped radical yields were measured as a function of spin trap concentration and of radiation dose.
Additionally, EPR spectra of long-lived free radicals were identified in irradiated imidazolium ILs at room temperature without a spin trap. While our computations indicate that the main observed splittings derive from the imidazole nitrogens and the neighboring hydrogens in radical cations, further experiments with isotopic substitution and calculations are underway in an effort to identify the precise structure of long-lived radicals.Radicals derived from sphingolipids and model compounds
The effect of ionization radiation on sphingolipids and their model compounds in aqueous solutions was investigated. Our studies were first to identify bioactive 2-hexadecenal among the major products of of γ-, UV- and HOCl-induced destruction of sphingolipids. This enabled us to derive mechanisms for the free radical damage of the polar part of sphingolipids. In the proposed mechanism, the formation of N-centered radicals is an important step.
Selected Publications
Lisovskaya A., K. Kanjana, D.M. Bartels. "One-electron redox kinetics of aqueous transition metal couples Zn2+/+, Co2+/+, and Ni2+/+ using pulse radiolysis." Phys. Chem. Chem. Phys. 22 (2020) 19046-19058. link
Tarabek P., A. Lisovskaya., D.M. Bartels. "γ-Radiolysis of room temperature ionic liquids. An EPR spin-trapping study." J. Phys. Chem. B. 123 (2019) 10837-49. link
Amaegberi N., G. Semenkova, Z. Kvacheva, A. Lisovskaya, S. Pinchuk, O. Shadyro. "2-Hexadecenal Inhibits Growth of c6 Glioma Cells." Cell Biochem. Funct. 37 (2019) 281-9. link
Janik I., A. Lisovskaya, D.M. Bartels. “Partial Molar Volume of the Hydrated Electron.” J. Phys. Chem. Lett. 10 (2019) 2220-6. link
Lisovskaya A., O. Shadyro. “ROS-induced Lipid Transformations without Oxygen Participation.” Chem. Phys. Lipids. 221 (2019) 176-83. link
Lisovskaya A., D.M. Bartels. “Reduction of CO2 by Hydrated Electrons in High Temperature Water.” Radiat. Phys. Chem.158 (2019) 61-63. link
Lisovskaya A., K. Procenko, O. Shadyro. “Photochemical Transformations of Sphingosine and Serinol in Aqueous and Ethanol Solutions.” High Energ. Chem. 51 (2017) 321–6. link